DEVELOPMENT AND CHARACTERIZATION OF TOPICAL OLEO-GEL SYSTEM OF CEFUROXIME AXETIL

Abstract

Oleogel is a semisolid matrix that may change shape when heated or cooled. It is made of an apolar substance that comes together on its own. Within a three-dimensional network made up of several oleogelators and co-oleogelators that interact chemically or physically, the phase is contained. The simplicity of manufacture and long-term stability of oleogel-based products make them unique. Using Span 65 as the oleogelator and Tween 80 as the co-oleogelator, this study sought to create an oleogel made from sunflower oil that included the antimicrobial drug Cefuroxime axetil for use in wound healing. By varying the amounts of Span 65 and Tween 80 in each formulation, we created a number of oleogel formulations. It was shown that 16% was the critical gelator concentration (CGC) of Span 65 in sunflower oil. Cefuroxime axetil was included into the oleogel for its antibacterial properties. The prepared oleogel was assessed for organoleptic characteristics, spreadability, oil binding capacity (%OBC), gel-sol transition temperature (Tg), viscosity, and release of drugs in vitro research. The optimization of several oleogels was conducted using a 32 complete factorial design, examining the influence of Span 65, Tween 80, and oil quantity on % OBC, viscosity, gel-sol transition temperature, and release of drugs in vitro at 1 hour and 5 hours. The optimal oleogel was determined to consist of a moderate quantity of Span65, an elevated quantity of Tween80, and a fixed volume of oil (25 ml). The improved oleogel underwent antibacterial and expedited stability studies.